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Through a careful tracing of the botanical presence of mulberry trees in Middlesex, Sandilands argues for a reading practice that takes plants seriously. Thinking with plants interrupts the tendency to consider literary plants primarily as motifs, metaphors or agents of crude naturalization. Sandilands insists on involving plants in reading Middlesex in order to take the novel in less anthropocentric directions: even as Cal enlists mulberries to signal inevitability, their own stories overflow the novel’s deterministic views of race, species, territory, and gender identity.