Document Type
Thesis
Degree Name
Master of Arts (MA)
Department
Psychology
Faculty/School
Faculty of Science
First Advisor
Linda Parker
Advisor Role
Thesis Supervisor
Abstract
Conditioned rejection reactions displayed in the taste reactivity test may reflect conditioned nausea in rats because they are exclusively produced by emetic agents. The present experiments demonstrated that pretreatment with the anti-nausea agent, ondansetron, interfered with the establishment of conditioned rejection reactions (Experiment 1) and interfered with the expression of previously established conditioned rejection reactions (Experiment 2). Ondansetron selectively interfered with conditioned nausea as reflected by conditioned rejection reactions because it did not modify the unconditioned rejection reactions elicited by unpalatable quinine solution (Experiment 2). Although ondansetron blocked the expression of the selective taste reactivity reaction of conditioned rejection, it did not modify the nonselective reactions of conditioned taste or place avoidance (Experiment 3). The results suggest that conditioned rejection reactions reflect conditioned nausea in rats that is attenuated by pretreatment with the anti-nausea agent, ondansetron.
Recommended Citation
Limebeer, Cheryl Lynn, "Ondansetron interferes with the establishment and expression of lithium-induced conditioned rejection reactions" (1999). Theses and Dissertations (Comprehensive). 682.
https://scholars.wlu.ca/etd/682
Convocation Year
1999
Convocation Season
Fall