Document Type

Thesis

Degree Name

Master of Science (MSc)

Department

Chemistry

Faculty/School

Faculty of Science

First Advisor

Louise N. Dawe

Advisor Role

Associate Professor and Supervisor

Abstract

Herein, the functional design of dissymmetric ligands for coordination systems is explored with a focus on their synthesis and structural characterization. The design strategy of these ligands incorporates the ability to coordinate both metal cations and anions along with a ligand site for other functionalization. Their synthesis, structural and other characterization, Hirshfeld surface analysis, and some metal-coordinated complexes are discussed. Chapter 1 introduces supramolecular and coordination chemistry, along with relevant literature that supports this research and outlines the thesis objective. Chapter 2 investigates the hydrogen bonding of a dissymmetric pyrimidine thioether ligand in its neutral form, water solvate, protonated nitrate salt, and a cobalt(II) complex, highlighting ligand adaptability in these forms. Chapter 3 describes the synthesis of a carboxylate functionalized amino-pyrazole ligand and analysis of its metal complexes with nickel and cobalt. This chapter highlights the expanded coordination capacity for this class of ligands based on versatile ligand functionalization and explores the incorporation of oxygen donors into the ligand framework. Chapter 4 describes the synthesis and fluorescent properties of bridged amino-pyrazole molecules through their reaction with carboxaldehydes demonstrating possible applications in ion sensing. Chapter 5 provides a general discussion and concluding statements of this research. The investigation of structure-property relationships contributes fundamentally to the understanding required for the development of new molecules that advance the field of supramolecular chemistry.

Convocation Year

2025

Convocation Season

Fall

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Available for download on Tuesday, September 15, 2026

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