Master of Arts (MA)
Faculty of Science
Linda A. Parker
The ability of the potential anti-addictive agent ibogaine to module the morphine-induced modification of quinine and sucrose palatability was assessed utilizing the taste reactivity test. Ibogaine (40mg/kg) was administered 24 hr prior to an injection of morphine (2 mg/kg), followed 30 min later by a 5 min intraoral infusion of 0.05% quinine solution (Experiment 1) or 10% sucrose solution (Experiment 2). Treatment with morphine enhanced the palatability of both quinine and sucrose solution. Morphine reduced the aversiveness of quinine solution during the 5 min of testing and enhanced ingestive responding to sucrose solution, however, only during min 1 of the 5 min test. Pretreatment with ibogaine 24 hr earlier, regardless of treatment condition, also enhanced the palatability of quinine and sucrose solution. However, there was no evidence that ibogaine modulated the effect of morphine on quinine or sucrose palatability.
Rideout, Hardy Joseph, "Effect of ibogaine on morphine: Induced modifications of palatability" (1995). Theses and Dissertations (Comprehensive). 567.