Document Type

Thesis

Degree Name

Master of Arts (MA)

Department

Psychology

Faculty/School

Faculty of Science

First Advisor

Linda A. Parker

Advisor Role

Thesis Supervisor

Abstract

The ability of the potential anti-addictive agent ibogaine to module the morphine-induced modification of quinine and sucrose palatability was assessed utilizing the taste reactivity test. Ibogaine (40mg/kg) was administered 24 hr prior to an injection of morphine (2 mg/kg), followed 30 min later by a 5 min intraoral infusion of 0.05% quinine solution (Experiment 1) or 10% sucrose solution (Experiment 2). Treatment with morphine enhanced the palatability of both quinine and sucrose solution. Morphine reduced the aversiveness of quinine solution during the 5 min of testing and enhanced ingestive responding to sucrose solution, however, only during min 1 of the 5 min test. Pretreatment with ibogaine 24 hr earlier, regardless of treatment condition, also enhanced the palatability of quinine and sucrose solution. However, there was no evidence that ibogaine modulated the effect of morphine on quinine or sucrose palatability.

Convocation Year

1995

Convocation Season

Spring

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