Master of Kinesiology (MKin)
Faculty of Science
Dr. Tom J. Hazell
Background: Intense-exercise has demonstrated an appetite suppressing effect post-exercise, however the involved mechanisms are not well understood. Lactate appears to be one viable mechanism as it has been found to bind to receptors on acylated ghrelin to inhibit release in cell culture. As sodium bicarbonate (NaHCO3) can alter lactate accumulation post-exercise without manipulating exercise-intensity, it presents an intriguing means to investigate lactate’s potential role. Purpose: To examine the role of lactate on appetite using NaHCO3 to alter blood lactate concentrations during high-intensity exercise. Methods: Eight recreationally active males completed two identical exercise sessions of low-volume high-intensity interval training (10 x 1 min intervals @~90%HRmax, 1 min active recovery), where they ingested either 0.4 g·kg-1 NaHCO3 (BICARB) or an equimolar amount of NaCl (PLAC) split into two doses 90 and 60 min prior to exercise. Blood samples were obtained at pre- as well as 30, 60, and 90 min post-exercise for measurement of acylated ghrelin, active glucagon-like peptide-1 (GLP-1), active peptide tyrosine tyrosine (PYY), and blood lactate. Appetite perceptions were assessed at the same time points. Results: Blood lactate was greater in BICARB post-exercise (P=0.005) and resulted in a blunted acylated ghrelin response at 90 min post-exercise compared to PLAC. Active GLP-1 only increased at 90 min post-exercise (P0.092), furthermore neither were different between conditions (P>0.429). Perceptions of appetite were not different between conditions but did not increase up until 60 min post-exercise (PConclusion:These findings further elucidate the important role of lactate in appetite regulation following intense intermittent-exercise.
Vanderheyden, Luke W., "EXPLORING LACTATE’S ROLE IN APPETITE REGULATION FOLLOWING HIGH-INTENSITY EXERCISE" (2018). Theses and Dissertations (Comprehensive). 2099.
Available for download on Wednesday, September 29, 2021