Master of Arts (MA)
Faculty of Science
The place conditioning paradigm was used to assess the ability of the noncompetitive NMDA receptor antagonist, M- 801 to interfere with drug-place associations. MK-801 (0.1 mg/kg, ip) attenuated a place preference produced by 10 mg/kg, but not by 3 or 5 mg/kg of amphetamine. MK-801 alone produced neither a place preference nor a place aversion. Interference with amphetamine place preference learning was not the result of state-dependent learning produced by MK-801. Furthermore, MK-801 did not interfere with the expression of a previously established amphetamine place preference. Pretreatment with MK-801 also interfered with lithium-induced conditioned place aversion learning. These results suggest that the attenuation of place preference conditioning produced by MK-801 is the result of its interference with learning rather than with the rewarding properties of drugs.
Toth, Jonathan Francis, "MK-801 interferes with the acquisition of amphetamine- and lithium-induced place conditioning" (1997). Theses and Dissertations (Comprehensive). 654.