Master of Arts (MA)
Faculty of Science
Linda A. Parker
Ibogaine, a proposed anti-addictive agent, has been found to interfere with the acquisition of a weak morphine-induced place preference. The purpose of the present experiments was to determine if ibogaine given at various times prior to a test for morphine place conditioning would interfere with the expression of a morphine (5 mg/kg) conditioned place preference. A single injection of 40 mg/kg ibogaine 24 h, 12 h or 4 h prior to the test did not interfere with the expression of a previously established morphine conditioned place preference (CPP). Two injections of 40 mg/kg ibogaine 48 h and 24 h or 24 h and 4 h prior to the test also did not interfere with the expression of a morphine place preference. Finally, a single injection of 80 mg/kg ibogaine was also ineffective in attenuating the expression of a morphine CPP. Ibogaine appears to be incapable of attenuating the expression of a previously established morphine CPP.
Luxton, Tracey Lyn, "Ibogaine fails to interrupt the expression of a previously established morphine place preference" (1995). Theses and Dissertations (Comprehensive). 562.